Two sample MR report
CDC42EP1_Interstitial Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.1019550 | 0.1622323 | 0.5572956 |
| Weighted median | 7 | 0.0246721 | 0.0089164 | 0.0056565 |
| Inverse variance weighted | 7 | 0.0226536 | 0.0069809 | 0.0011741 |
| Simple mode | 7 | 0.0268992 | 0.0132408 | 0.0884755 |
| Weighted mode | 7 | 0.0261374 | 0.0126965 | 0.0852179 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.357692 | 5 | 0.9288847 |
| Inverse variance weighted | 1.948745 | 6 | 0.9243516 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.082055 | 0.1067314 | 0.4767374 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 9.38e-05 | 0 | TRUE | 0.3588016 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
